Contents
Preliminary studies supporting the rationale of ICS-RECODE study
Preliminary studies supporting the rationale of the ICS-RECODE study
Post-hoc analysis of the ISOLDE trial, demonstrating that blood eosinophils measured while patients are receiving corticosteroids are not equivalent to blood eosinophils measured while patients are not receiving ICS. This study also established eosinophils change as a potential biomarker
- Mathioudakis AG, Bikov A, Foden P, Lahousse L, Brusselle G, Singh D, Vestbo J. Change in blood eosinophils following treatment with inhaled corticosteroids may predict long-term clinical response in COPD. Eur Respir J. 2020;55(5):1902119. doi: 10.1183/13993003.02119-2019. Link to full text
Post-hoc analysis of the FLAME trial further providing further evidence that blood eosinophils measured on ICS treatment are inferior to measurements off ICS, and supporting on treatment BEC change as a promising biomarker for guiding ICS use in COPD.
Mathioudakis AG, Bate S, Sivapalan P, Jensen JS, Singh D, Vestbo J. Rethinking Blood Eosinophils for Assessing Inhaled Corticosteroids Response in COPD: A Post Hoc Analysis From the FLAME Trial. Chest. 2024 Nov;166(5):987-997. doi: 10.1016/j.chest.2024.06.3790. Link to full text
ICS-RECODE: Study protocol
The ICS-RECODE study protocol.
- Bate S, Fortescue R, Fullwood C, Sperrin M, Simmonds M, Fally M, Hansel J, Miligkos M, Manohar S, Howlett E, Linnell J, Preston A, the ICS-RECODE group, Woodcock AA, Singh D, Stewart L, Vestbo J, Mathioudakis AG. Predictors of treatment REsponse to inhaled corticosteroids (ICS) in Chronic Obstructive pulmonary disease: randomised controlled trials individual participant Data re-Evaluation–protocol of the ICS-RECODE individual participant data meta-analysis. BMJ Open. 2025;15:e095541. doi: 10.1136/bmjopen-2024-095541. Link to full text
Main results
Coming soon!
Methodological findings
Conference abstracts
- Bate S, Mathioudakis AG, and the ICS-RECODE team. The challenges of an individual participant data meta-analysis using pharmaceutical data: lessons from ICS RECODE. NIHR Statistics Group Annual Conference 2024. Sheffield, June 2024.