{"id":14,"date":"2023-12-04T12:49:46","date_gmt":"2023-12-04T12:49:46","guid":{"rendered":"https:\/\/ics-recode.eu\/?page_id=14"},"modified":"2025-03-10T00:12:17","modified_gmt":"2025-03-10T00:12:17","slug":"results-publications","status":"publish","type":"page","link":"https:\/\/ics-recode.eu\/?page_id=14","title":{"rendered":"Results &#8211; Publications"},"content":{"rendered":"\n<p class=\"has-large-font-size\"><\/p>\n\n\n\n<p class=\"has-large-font-size\"><strong>Contents<\/strong><\/p>\n\n\n\n<p><a href=\"#PrelimStudies\" data-type=\"internal\" data-id=\"#PrelimStudies\">Preliminary studies supporting the rationale of ICS-RECODE study<\/a><\/p>\n\n\n\n<p><a href=\"#StudyProtocol\" data-type=\"internal\" data-id=\"#StudyProtocol\">Study protocol<\/a><\/p>\n\n\n\n<p><a href=\"#MainResults\">Main results<\/a><\/p>\n\n\n\n<p><a href=\"#MethodsFindings\">Methodological findings<\/a><\/p>\n\n\n\n<div class=\"wp-block-group alignfull has-base-background-color has-background has-global-padding is-layout-constrained wp-container-core-group-is-layout-d89aad35 wp-block-group-is-layout-constrained\" id=\"PrelimStudies\" style=\"margin-top:0;margin-bottom:0;padding-top:var(--wp--preset--spacing--50);padding-right:var(--wp--preset--spacing--50);padding-bottom:var(--wp--preset--spacing--50);padding-left:var(--wp--preset--spacing--50)\">\n<div class=\"wp-block-columns alignwide is-layout-flex wp-container-core-columns-is-layout-549b0c86 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-x-large-font-size\">Preliminary studies supporting the rationale of the ICS-RECODE study<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p><strong>Post-hoc analysis of the ISOLDE trial, demonstrating that blood eosinophils measured while patients are receiving corticosteroids are not equivalent to blood eosinophils measured while patients are not receiving ICS. This study also established eosinophils change as a potential biomarker<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Mathioudakis AG, Bikov A, Foden P, Lahousse L, Brusselle G, Singh D, Vestbo J. <em>Change in blood eosinophils following treatment with inhaled corticosteroids may predict long-term clinical response in COPD.<\/em> <strong>Eur Respir J.<\/strong> 2020;55(5):1902119. doi: 10.1183\/13993003.02119-2019. <a href=\"http:\/\/doi.org\/10.1183\/13993003.02119-2019\" data-type=\"link\" data-id=\"http:\/\/erj.ersjournals.com\/cgi\/pmidlookup?view=long&amp;pmid=32108044\" target=\"_blank\" rel=\"noreferrer noopener\">Link to full text<\/a><\/li>\n<\/ul>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image aligncenter size-full\"><img fetchpriority=\"high\" decoding=\"async\" width=\"440\" height=\"330\" src=\"https:\/\/ics-recode.eu\/wp-content\/uploads\/2025\/03\/F6.medium.gif\" alt=\"\" class=\"wp-image-209\"\/><\/figure>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group alignfull has-accent-background-color has-background has-global-padding is-layout-constrained wp-container-core-group-is-layout-669513ed wp-block-group-is-layout-constrained\" style=\"margin-top:0;margin-bottom:0;padding-top:var(--wp--preset--spacing--50);padding-right:var(--wp--preset--spacing--50);padding-bottom:var(--wp--preset--spacing--50);padding-left:var(--wp--preset--spacing--50)\">\n<div class=\"wp-block-group alignwide has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-columns alignfull are-vertically-aligned-top is-layout-flex wp-container-core-columns-is-layout-1da03c2a wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-vertically-aligned-top is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:70%\">\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" width=\"735\" height=\"448\" src=\"https:\/\/ics-recode.eu\/wp-content\/uploads\/2025\/03\/FLAME_Algorithm.jpg\" alt=\"\" class=\"wp-image-205\" srcset=\"https:\/\/ics-recode.eu\/wp-content\/uploads\/2025\/03\/FLAME_Algorithm.jpg 735w, https:\/\/ics-recode.eu\/wp-content\/uploads\/2025\/03\/FLAME_Algorithm-300x183.jpg 300w\" sizes=\"(max-width: 735px) 100vw, 735px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-top is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:75%\">\n<p><strong>Post-hoc analysis of the FLAME trial further providing further evidence that blood eosinophils measured on ICS treatment are inferior to measurements off ICS, and supporting on treatment BEC change as a promising biomarker for guiding ICS use in COPD.<\/strong><\/p>\n\n\n\n<p>Mathioudakis AG, Bate S, Sivapalan P, Jensen JS, Singh D, Vestbo J. Rethinking Blood Eosinophils for Assessing Inhaled Corticosteroids Response in COPD: A Post Hoc Analysis From the FLAME Trial. Chest. 2024 Nov;166(5):987-997. doi: 10.1016\/j.chest.2024.06.3790. <a href=\"http:\/\/doi.org\/10.1016\/j.chest.2024.06.3790\" data-type=\"link\" data-id=\"doi.org\/10.1016\/j.chest.2024.06.3790\" target=\"_blank\" rel=\"noreferrer noopener\">Link to full text<\/a><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group alignfull has-accent-background-color has-background has-global-padding is-layout-constrained wp-container-core-group-is-layout-669513ed wp-block-group-is-layout-constrained\" id=\"StudyProtocol\" style=\"margin-top:0;margin-bottom:0;padding-top:var(--wp--preset--spacing--50);padding-right:var(--wp--preset--spacing--50);padding-bottom:var(--wp--preset--spacing--50);padding-left:var(--wp--preset--spacing--50)\">\n<div class=\"wp-block-group alignwide has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-columns alignwide is-layout-flex wp-container-core-columns-is-layout-1da03c2a wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-x-large-font-size\">ICS-RECODE: Study protocol<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\">\n<p><strong>The ICS-RECODE study protocol.<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Bate S, Fortescue R, Fullwood C, Sperrin M, Simmonds M, Fally M, Hansel J, Miligkos M, Manohar S, Howlett E, Linnell J, Preston A, the ICS-RECODE group, Woodcock AA, Singh D, Stewart L, Vestbo J, Mathioudakis AG. <em>Predictors of treatment REsponse to inhaled corticosteroids (ICS) in Chronic Obstructive pulmonary disease: randomised controlled trials individual participant Data re-Evaluation\u2013protocol of the ICS-RECODE individual participant data meta-analysis.<\/em> <strong>BMJ Open.<\/strong> 2025;15:e095541. doi: 10.1136\/bmjopen-2024-095541. <a href=\"http:\/\/doi.org\/10.1136\/bmjopen-2024-095541\" data-type=\"link\" data-id=\"http:\/\/erj.ersjournals.com\/cgi\/pmidlookup?view=long&amp;pmid=32108044\" target=\"_blank\" rel=\"noreferrer noopener\">Link to full text<\/a><\/li>\n<\/ul>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img decoding=\"async\" width=\"500\" height=\"1280\" src=\"https:\/\/ics-recode.eu\/wp-content\/uploads\/2025\/03\/bmjopen-2025-March-15-3-F1.large_.jpg\" alt=\"\" class=\"wp-image-248\" style=\"width:388px;height:auto\" srcset=\"https:\/\/ics-recode.eu\/wp-content\/uploads\/2025\/03\/bmjopen-2025-March-15-3-F1.large_.jpg 500w, https:\/\/ics-recode.eu\/wp-content\/uploads\/2025\/03\/bmjopen-2025-March-15-3-F1.large_-117x300.jpg 117w, https:\/\/ics-recode.eu\/wp-content\/uploads\/2025\/03\/bmjopen-2025-March-15-3-F1.large_-400x1024.jpg 400w\" sizes=\"(max-width: 500px) 100vw, 500px\" \/><\/figure>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group alignfull has-accent-background-color has-background has-global-padding is-layout-constrained wp-container-core-group-is-layout-669513ed wp-block-group-is-layout-constrained\" id=\"MainResults\" style=\"margin-top:0;margin-bottom:0;padding-top:var(--wp--preset--spacing--50);padding-right:var(--wp--preset--spacing--50);padding-bottom:var(--wp--preset--spacing--50);padding-left:var(--wp--preset--spacing--50)\">\n<div class=\"wp-block-group alignwide has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-columns alignwide is-layout-flex wp-container-core-columns-is-layout-1da03c2a wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-x-large-font-size\">Main results<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\">\n<p><strong>Coming soon!<\/strong><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group alignfull has-accent-background-color has-background has-global-padding is-layout-constrained wp-container-core-group-is-layout-669513ed wp-block-group-is-layout-constrained\" id=\"MethodsFindings\" style=\"margin-top:0;margin-bottom:0;padding-top:var(--wp--preset--spacing--50);padding-right:var(--wp--preset--spacing--50);padding-bottom:var(--wp--preset--spacing--50);padding-left:var(--wp--preset--spacing--50)\">\n<div class=\"wp-block-group alignwide has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-columns alignwide is-layout-flex wp-container-core-columns-is-layout-1da03c2a wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-x-large-font-size\">Methodological findings<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"256\" height=\"256\" src=\"https:\/\/ics-recode.eu\/wp-content\/uploads\/2025\/03\/2643513.png\" alt=\"\" class=\"wp-image-298\" style=\"width:351px;height:auto\" srcset=\"https:\/\/ics-recode.eu\/wp-content\/uploads\/2025\/03\/2643513.png 256w, https:\/\/ics-recode.eu\/wp-content\/uploads\/2025\/03\/2643513-150x150.png 150w\" sizes=\"(max-width: 256px) 100vw, 256px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\">\n<p><strong>Conference abstracts<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><span style=\"text-decoration: underline;\">Bate S<\/span>,&nbsp;Mathioudakis AG, and the ICS-RECODE team. The challenges of an individual participant data meta-analysis using pharmaceutical data: lessons from ICS RECODE. NIHR Statistics Group Annual Conference 2024. Sheffield, June 2024.&nbsp;&nbsp;<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Contents Preliminary studies supporting the rationale of ICS-RECODE study Study protocol Main results Methodological findings Preliminary studies supporting the rationale of the ICS-RECODE study Post-hoc analysis of the ISOLDE trial, demonstrating that blood eosinophils measured while patients are receiving corticosteroids are not equivalent to blood eosinophils measured while patients are not receiving ICS. This study [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-14","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/ics-recode.eu\/index.php?rest_route=\/wp\/v2\/pages\/14","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ics-recode.eu\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/ics-recode.eu\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/ics-recode.eu\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/ics-recode.eu\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=14"}],"version-history":[{"count":45,"href":"https:\/\/ics-recode.eu\/index.php?rest_route=\/wp\/v2\/pages\/14\/revisions"}],"predecessor-version":[{"id":327,"href":"https:\/\/ics-recode.eu\/index.php?rest_route=\/wp\/v2\/pages\/14\/revisions\/327"}],"wp:attachment":[{"href":"https:\/\/ics-recode.eu\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=14"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}